Inhibition of histone acetyltransferase by glycosaminoglycans
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چکیده
منابع مشابه
Inhibition of histone acetyltransferase function of p300 by PKCy
Protein kinase Cy (PKCy) is one of the functionally distinct isoforms in PKC family. p300 is a histone acetyltransferase/transcription coactivator. They share certain properties, such as ubiquitous expression, growth and tumor suppression, and ability to enhance differentiation and apoptosis. In this study, we found that PKCy but not classical PKC, specifically phosphorylates p300 at serine 89 ...
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Most histone acetyltransferases (HATs) function as multisubunit complexes in which accessory proteins regulate substrate specificity and catalytic efficiency. Rtt109 is a particularly interesting example of a HAT whose specificity and catalytic activity require association with either of two histone chaperones, Vps75 or Asf1. Here, we utilize biochemical, structural, and genetic analyses to pro...
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It is well established that the coordinated regulation of activity-dependent gene expression by the histone acetyltransferase (HAT) family of transcriptional coactivators is crucial for the formation of contextual fear and spatial memory, and for hippocampal synaptic plasticity. However, no studies have examined the role of this epigenetic mechanism within the infralimbic prefrontal cortex (ILP...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2008
ISSN: 0730-2312
DOI: 10.1002/jcb.21803